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This localized delivery minimizes systemic absorption and potential side effects while maximizing the antifungal effect within the sinus cavities

Lynch R, Diggins EL, Connors SL, Zimmerman AW, Singh K, Liu H, et al

They are present in dendritic cells, endothelial cells, macrophages, B cells, and T cells

High levels of NO, in conjunction with ROS, can lead to the formation of peroxynitrite, a potent oxidant that can induce lipid peroxidation, DNA damage, and protein modification 56